Replicants are bioengineered humans, once designed by the Tyrell Corporation for use Off-world. After a series of violent rebellions, their manufacture was prohibited, and Tyrell Corp went bankrupt. Niander Wallace acquired the remains of Tyrell Corp and created a new line of Replicants who obey. A Replicant underground survives, led by the former combat model Freysa and her human partner Aahna Ashina, known as Ash, formerly a Blade Runner. Twenty years ago, in 2019, Ash spared the Replicant Isobel Selwyn, a replica of industrialist Alexander Selwyn's wife. Together with Alexander's human daughter Cleo, Isobel escaped to the Off-world colonies. Searching for the late Alexander Selwyn's research into Replicant physiology, Niander Wallace sent his creation Luv, the first Replicant Blade Runner, to hunt down both Cleo and Isobel, believing that Isobel holds the secret to Replicant fertility. To aid Luv in her mission, Wallace manufactured a new Replicant created from Ash's DNA. Having rescued Isobel and Cleo, Ash has now returned to her beloved Los Angeles and to her lover, Freysa. Knowing that Niander Wallace is still hunting the two women Ash has decided to take the fight to Wallace himself and has to find a way of infiltrating his heavily guarded penthouse complex. While visiting ex-Blade Runner Carl Moreau, Ash encounters her Replicant double and manages to capture her.